کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5628756 1579893 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced thalamic volume in patients with Electrical Status Epilepticus in Sleep
ترجمه فارسی عنوان
کاهش حجم تالاموم در بیماران مبتلا به صرع برق در خواب
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- A proportion of children with ESES have a thalamic lesion while a majority does not.
- We evaluated thalamic volume in patients with ESES and normal MRI.
- ESES patients with normal MRI have smaller relative thalamic volume than controls.
- Reduced relative volume is present controlling for age and total brain volume.

PurposeTo test whether patients with Electrical Status Epilepticus in Sleep (ESES) and normal neuroimaging have a smaller thalamic volume than expected for age and for total brain volume.MethodsCase-control study comparing three groups of subjects of 4-14 years of age and normal magnetic resonance imaging: 1) ESES patients, 2) patients with refractory epilepsy control group, and 3) healthy controls. Thalamic and total brain volumes were calculated using an algorithm for automatic segmentation and parcellation of magnetic resonance imaging.ResultsEighteen ESES patients, 29 refractory epilepsy controls and 51 healthy controls were included. The median (p25-p75) age was 8.8 (7.5-10.3) years for ESES patients, 11 (7-12) years for healthy controls, and 9 (6.3-11.2) years for refractory epilepsy controls. After correcting for total brain volume and age, the left thalamus was not statistically significantly smaller in ESES patients than in healthy controls (p = 0.077), in ESES patients than in refractory epilepsy controls (p = 0.056); but the right thalamus was smaller in ESES patients than in healthy controls (p = 0.044), and in ESES patients than in refractory epilepsy controls (p = 0.033).ConclusionPatients with ESES and normal magnetic resonance imaging have smaller relative thalamic volume controlling for age and total brain volume.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 130, February 2017, Pages 74-80
نویسندگان
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