Case Report & Case SeriesTreatment and long-term follow-up of primary CNS classical Hodgkin's lymphoma - A case report and review of the literature

- CNS Classical Hodgkin's Lymphoma is a rarely reported clinical entity.
- Due to the scarcity of clinical reports CNS Classical Hodgkin's lymphoma has historically been a controversial diagnosis.
- Surgical resection and radiation therapy can result in long term survival.

Unlike non-Hodgkin's lymphoma, central nervous system involvement with classical Hodgkin's lymphoma is exceedingly rare, thus information regarding treatment and prognostication of the disease is lacking. We present the case of a 47 year old female who presented with a left parietal dural-based lesion which proved to be Stage IE primary CNS classical Hodgkin's lymphoma. After surgery and whole brain radiation therapy, the patient has remained in complete remission over nine years. Despite the dearth of information available regarding CNS Hodgkin's lymphoma, our case is consistent with the findings in the literature that long-term survival is possible in patients achieving a complete response to treatment, especially in those patients who present with sole CNS involvement. To our knowledge, this represents the longest reported survival in the literature and contributes to our understanding of prognosis in patients with CNS Hodgkin's lymphoma.