کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5629763 1580274 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lab resourceAssociation of medial prefrontal cortex connectivity with consciousness level and its outcome in patients with acquired brain injury
ترجمه فارسی عنوان
منابع آزمایشگاهی ارتباط متقابل قشر پیشانی با سطح آگاهی و نتیجه آن در بیماران مبتلا به آسیب مغزی به دست آمده
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Structural integrity of the mPFC in brain-injured patients was guaranteed before FC analysis.
- The role of mPFC in modulating conscious awareness was exhibited.
- An early prognostic indicator of consciousness recovery was explored.

Medial prefrontal cortex (mPFC) is usually known for participating in virtually all self related processing. However, few have investigated the role of mPFC in modulating conscious awareness. This study aimed to depict the relationship between the mPFC connectivity and the severity and outcome of the disorders of consciousness (DOC) among patients with acquired brain injury. Thirty-four patients with DOC (17 in a minimally conscious state and 17 in an unresponsive wakefulness syndrome/vegetative state) and 11 healthy controls were recruited, underwent clinical assessment and resting-state functional MRI scan, and were further followed up to evaluate recovery outcome using the Glasgow Outcome Scale. The mPFC connectivity was then analyzed, by comparing DOC patients to healthy controls at baseline, and by comparing “recovered consciousness” and “non-recovered consciousness” patients at follow-up, as identified by graph theory. As a result, enhanced mPFC connectivity against weakened posteromedial cortex connectivity was observed in a minimally conscious state, not in an unresponsive wakefulness syndrome/vegetative state. Besides, increased mPFC connectivity was significantly associated with consciousness recovery. In conclusion, the mPFC connectivity could possibly serve as a mark to track the severity and outcome of DOC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 42, August 2017, Pages 160-166
نویسندگان
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