کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5645917 | 1407045 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Eruptive melanocytic nevi with malignant transformations and the connection to BRAF and p16 mutations
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Eruptive melanocytic nevi (EMN) is a rare phenomenon with an unclear pathogenesis. Mutation on a molecular basis has been proposed, but insufficient data are available to confirm this hypothesis. Theoretically, the possibility of malignant transformation is high, but no previous definite cases had been reported. Herein, we report the first case of a patient with EMN in whom hypopharyngeal low-grade melanocytic malignancies were detected using a fibrolaryngoscope. BRAF activation and p16 mutations were discovered through real-time polymerase chain reaction and immunohistochemical staining on EMN tissue samples, respectively. The significance of these findings has yet to be determined.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Dermatologica Sinica - Volume 35, Issue 1, March 2017, Pages 30-33
Journal: Dermatologica Sinica - Volume 35, Issue 1, March 2017, Pages 30-33
نویسندگان
Ting-Hua Yang, Kuo-Hsien Wang, Hsiou-Hsin Tsai, Jan-Show Chu,