کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5648748 | 1587814 | 2017 | 7 صفحه PDF | دانلود رایگان |
- Three SNPs (rs613791, rs523604, rs638893) showed significant association with vitiligo in the study in Han Chinese population.
- Previously reported SNP rs638893 was replicated, two newly identified SNPs (rs613791 and rs523604) were all independent of the reported SNP rs638893, and they were also independent of each other.
- SNP rs523604 and rs613791 are located in CXCR5, and CXCR5 is crucial for follicular helper T cells (Tfh), which plays a key role in the pathogenesis of autoimmune diseases.
BackgroundVitiligo is an autoimmune disease, characterized by progressive loss of skin pigmentation, which is caused by the interactions of multiple factors, such as heredity, immunity and environment. Recently, a single nucleotide polymorphism (SNP) rs638893 at 11q23.3 region was identified as a risk factor for vitiligo in genome-wide association studies and multiple SNPs in this region have been associated with other autoimmune diseases.ObjectiveThis study aims to identify additional susceptibility variants associated with vitiligo at 11q23.3 in the Chinese Han population.MethodsWe selected and genotyped 26 SNPs at 11q23.3 in an independent cohort including 2924 cases and 4048 controls using the Sequenom MassArray iPLEX® system. Bonferroni adjustment was used for multiple comparisons and P value <1.92Â ÃÂ 10â3 (0.05/26) was considered statistically significant.ResultsThe A allele of rs613791 and G allele of rs523604 located in CXCR5 were observed to be significantly associated with vitiligo (ORÂ =Â 1.21, 95% CI: 1.11-1.31, PÂ =Â 1.20Â ÃÂ 10â5; ORÂ =Â 1.14, 95% CI: 1.07-1.23, PÂ =Â 1.90Â ÃÂ 10â4, respectively). The C allele of rs638893 (a previously reported one) located upstream of DDX6 was also significantly associated with vitiligo (ORÂ =Â 1.25, 95% CI: 1.12-1.38, PÂ =Â 3.04Â ÃÂ 10â5). The genotypes distribution of 3 SNPs also showed significant differences between case and control (rs613791: PÂ =Â 7.00Â ÃÂ 10â6, rs523604: PÂ =Â 4.00Â ÃÂ 10â3, rs638893: PÂ =Â 1.20Â ÃÂ 10â5, respectively). The two newly identified SNPs (rs613791 and rs523604) showed independent associations with vitiligo by linkage disequilibrium analysis and conditional logistic regression.ConclusionsThe study identified two new independent signals in the associated locus 11q23.3 for vitiligo. The presence of multiple independent variants emphasizes an important role of this region in disease susceptibility.
Journal: Journal of Dermatological Science - Volume 88, Issue 1, October 2017, Pages 103-109