کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5654842 1589411 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy
چکیده انگلیسی


- Antibody responses to HCV are lower in untreated HIV/HCV patients than HCV patients.
- HCV-specific antibody responses increase during antiretroviral therapy.
- Neutralising antibodies may contribute to control of viral replication in some patients.

Antibody responses have not been fully characterised in chronically HIV/HCV patients receiving antiretroviral therapy (ART). Seventeen HIV/HCV patients receiving ART were followed for a median (range) interval of 597 (186-766) weeks. Prior to ART, HIV/HCV patients had lower levels of antibodies reactive with HCV core and JFH-1, and lower genotype cross-reactive neutralising antibodies (nAb) titres, than HCV patients. Levels of JFH-1 reactive antibody increased on ART, irrespective of CD4+ T-cell counts or changes in serum ALT levels. The appearance of nAb coincided with control of HCV viral replication in five HIV/HCV patients. In other patients, HCV viral loads remained elevated despite nAb responses. Sustained virological responses following HCV therapy were associated with reduced antibody responses to JFH-1 and core but elevated responses to non-structural proteins. We conclude that nAb responses alone may fail to clear HCV, but contribute to control of viral replication in some HIV/HCV patients responding to ART.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 179, June 2017, Pages 54-63
نویسندگان
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