کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5660302 1590324 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical outcomes of donation after circulatory death liver transplantation in primary sclerosing cholangitis
ترجمه فارسی عنوان
نتایج کلینیکی اهدا پس از پیوند کبد مرگ و میر در کلانژیت اسکلروزیس اولیه
کلمات کلیدی
کلانژیت اسکلروزیس اولیه، پیوند کبد، کولیت زخم، ضایعه صفراوی ایسکمیک، سونوگرافی صفراوی غیر آناستوموتیک، ترومبوز شریان کبدی، غیر اهدا کننده قلبی، طبقه بندی خطر،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی


- Outcomes of DCD vs. DBD liver transplantation in PSC are compared.
- Operation times, need for intensive care support, and incidence of renal injury were not increased.
- DCD transplantation in PSC did not increase risk of non-anastomotic biliary strictures overall.
- Incidence of ischaemic-type biliary lesions is heightened in the first year for DCD recipients.
- Overall risk of hepatic artery thrombosis is greatest in patients with inflammatory bowel disease.
- Graft survival is not significantly different for PSC patients receiving a DCD vs. DBD liver.

Background & AimPrimary sclerosing cholangitis (PSC) is a progressive fibro-inflammatory cholangiopathy for which liver transplantation is the only life-extending intervention. These patients may benefit from accepting liver donation after circulatory death (DCD), however their subsequent outcome is unknown. The aim of this study was to determine the clinical impact of using DCD liver grafts in patients specifically undergoing transplantation for PSC.MethodsClinical outcomes were prospectively evaluated in PSC patients undergoing transplantation from 2006 to 2016 stratified by donor type (DCD, n = 35 vs. donation after brainstem death [DBD], n = 108).ResultsIn liver transplantation for PSC; operating time, days requiring critical care support, total ventilator days, incidence of acute kidney injury, need for renal replacement therapy (RRT) or total days requiring RRT were not significantly different between DCD vs. DBD recipients. Although the incidence of ischaemic-type biliary lesions was greater in the DCD group (incidence rate [IR]: 4.4 vs. 0 cases/100-patient-years; p <0.001) there was no increased risk of post-transplant biliary strictures overall (hazard ratio [HR]: 1.20, 0.58-2.46; p = 0.624), or in sub-analysis specific to anastomotic strictures or recurrent PSC, between donor types. Graft loss and mortality rates were not significantly different following transplantation with DCD vs. DBD livers (IR: 3.6 vs. 3.1 cases/100-patient-years, p = 0.34; and 3.9 vs. 4.7, p = 0.6; respectively). DCD liver transplantation in PSC did not impart a heightened risk of graft loss (HR: 1.69, 0.58-4.95, p = 0.341) or patient mortality (0.75, 0.25-2.21, p = 0.598).ConclusionTransplantation with DCD (vs. DBD) livers in PSC patients does not impact graft loss or patient survival. In an era of organ shortage, DCD grafts represent a viable therapeutic option for liver transplantation in PSC patients.Lay summary: This study examines the impact of liver transplantation in primary sclerosing cholangitis (PSC) with organs donated after circulatory death (DCD), compared to donation after brainstem death (DBD). We show that in appropriately selected patients, the outcomes for DCD transplantation mirror those using DBD livers, with no significant differences in complication rate, patient survival or transplanted liver survival. In an era of organ shortage and increasing wait-list times, DCD livers represent a potential treatment option for transplantation in PSC.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 67, Issue 5, November 2017, Pages 957-965
نویسندگان
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