کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5662636 1590489 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does desmopressin produce more cognitive problems and delirious symptoms in independent geriatric outpatients with nocturnal polyuria (NP)?
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب سالمندان و علم پیری شناسی
پیش نمایش صفحه اول مقاله
Does desmopressin produce more cognitive problems and delirious symptoms in independent geriatric outpatients with nocturnal polyuria (NP)?
چکیده انگلیسی

ObjectivesTo show a relation between the nocturnal polyuria, its therapy with desmopressin and cognitive alterations and delirious symptoms.MethodologyProspective, randomized, mono-center, mono-national, double-blind, placebo-controlled, fixed-dose, parallel group comparative trial, with 110 patients, 55 patients per treatment group using desmopressin acetate nasal spray, strength: 0.1 mg/mL, nasal once a day of 10 μg/spray blast.MeasurementNP positive patients (> 33% nocturnal urine output volume [ADH positive or negative]) were treated over 10 days with intranasal spray in the evening time (7 p.m.), drug or placebo. On day 2, 5 and 10 the patients were interviewed about voiding frequency, sleeping behavior and subjective and cognitive alterations and delirium.ResultsThere was no correlation to be found between NP and the incidence of delirious symptoms or cognitive alterations. But the Mann-Whitney U-Test showed a superiority for delirious symptoms and forgetfulness under effective treatment with desmopressin (P = 0.0279). Delirious symptoms showed to be significantly more frequent under desmopressin treatment in the final assessment (results last value, P = 0.0297; changes from baseline, P = 0.0340; percentage changes from baseline, P = 0.0373). The variance analysis with repeated measures approved no significant augmentation of delirious symptoms under desmopressin.ConclusionIn this 10-day, clinical trial desmopressin was not significantly correlated with more delirious symptoms and forgetfulness in independent geriatric outpatients. NP and the disturbance of sleep were not correlated with delirium or cognitive decline.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Geriatric Medicine - Volume 8, Issue 4, September 2017, Pages 349-353
نویسندگان
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