کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5664652 | 1407716 | 2017 | 4 صفحه PDF | دانلود رایگان |
BackgroundThere is a need of comprehensive work dealing with the quality of plasma for fractionation with respect to the IgG content as today most plasma derivates are used to treat patients with immunodeficiencies and autoimmune disorders. Therefore, a prospective study was carried out to analyse IgG levels before plasmapheresis and every 200 ml collected plasma.Materials and methodsFifty-four experienced plasmapheresis donors were recruited for subsequent 850 ml plasmapheresis using the Aurora Plasmapheresis System. DonorŠperipheral blood counts were analysed before and after plasmapheresis using an electronic counter. Total protein, IgG and citrate were measured turbidometrically before, during and after apheresis as well as in the plasma product. Furthermore, platelets, red and white blood cells were analysed as parameters of product quality.ResultsAn average of 2751 ± 247 ml blood was processed in 47 ± 6 min. The collected plasma volume was 850 ± 1 mL and citrate consumption was 177 ± 15 mL. A continuous drop of donors' IgG level was observed during plasmapheresis. The drop was 13% of the IgG baseline value at 800 mL collected plasma. Total protein, IgG and cell counts of the plasma product met current guidelines of plasma for fractionation.ConclusionDonors' IgG levels during apheresis showed a steady decrease without compromising the quality of plasma product.
Journal: Transfusion and Apheresis Science - Volume 56, Issue 3, June 2017, Pages 417-420