کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5667322 1592036 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of long-lasting insecticidal nets on prevalence of subclinical malaria among children in the presence of pyrethroid resistance in Anopheles culicifacies in Central India
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Impact of long-lasting insecticidal nets on prevalence of subclinical malaria among children in the presence of pyrethroid resistance in Anopheles culicifacies in Central India
چکیده انگلیسی


- Baseline prevalence of subclinical malaria infection was 6.1% with predominance of P. falciparum infections (67.6%).
- Subclinical malaria prevalence were significantly reduced by 84% in the follow up survey compared with baseline.

BackgroundSubclinical (asymptomatic) cases of malaria could be a major barrier to the success of malaria elimination programs. This study has evaluated the impact of long-lasting insecticidal nets (LLINs) on the prevalence of subclinical malaria in the presence of pyrethroid resistance in the main malaria vector Anopheles culicifacies on malaria transmission among a cohort of children in villages of the Keshkal sub-district in Chhattisgarh state.MethodsA cohort of 6582 children ages less than 14 years was enrolled from 80 study clusters. Post monsoon survey was carried out at baseline before LLIN distribution, and 5862 children were followed up in the subsequent year. Study outcomes included assessment of subclinical malarial infections and use of LLINs among the study cohort in the presence of varied levels of pyrethroid resistance.FindingsIn the baseline survey, the proportion of subclinical malaria was 6·1%. LLIN use during the previous night was 94·8%. Overall, prevalence of subclinical malaria was significantly reduced to 1% (p < 0·001) in the second survey. LLIN users were protected from malaria (OR: 0·25, 95% CI = 0·12-0·52, p < 0.001) and subclinical malaria (OR: 0·25, 95% CI = 0·11-0·58, p = 0·001) despite the presence of pyrethroid resistance in the study area.InterpretationIn this low transmission area, sleeping under LLINs significantly reduced the burden of malaria among children. In the presence of pyrethroid resistant malaria vector, a high LLIN use of 94·5% was observed to have significantly brought down the proportion of subclinical malaria among the cohort children.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Infectious Diseases - Volume 57, April 2017, Pages 123-129
نویسندگان
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