|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5669380||1407960||2017||7 صفحه PDF||سفارش دهید||دانلود کنید|
SummaryObjectiveTo explore and quantify the relative strengths of the genetic contribution vs the contribution of modifiable environmental factors to severe osteoarthritis (OA) having progressed to total joint arthroplasty.DesignIncident data from the Norwegian Arthroplasty Registry were linked with the Norwegian Twin Registry on the National ID-number in 2014 in a population-based prospective cohort study of same-sex twins born 1915-60 (53.4% females). Education level and height/weight were self-reported and Body Mass Index (BMI) calculated. The total follow-up time was 27 years for hip arthroplasty (1987-2014, 424,914 person-years) and 20 years for knee arthroplasty (1994-2014, 306,207 person-years). We estimated concordances and the genetic contribution to arthroplasty due to OA in separate analyses for the hip and knee joint.ResultsThe population comprised NÂ =Â 9058 twin pairs (NÂ =Â 3803 monozygotic (MZ), NÂ =Â 5226 dizygotic (DZ)). In total, 73% (95% confidence intervals (CI)Â =Â 66-78%) and 45% (95% CIÂ =Â 30-58%) of the respective variation in hip and knee arthroplasty could be explained by genetic factors. Zygosity (as a proxy for genetic factors) was associated with hip arthroplasty concordance over time when adjusted for sex, age, education and BMI (HRÂ =Â 2.98, 95% CIÂ =Â 1.90-4.67 for MZ compared to DZ twins). Knee arthroplasty was to a greater extent dependent on BMI when adjusted for zygosity and the other covariates (HRÂ =Â 1.15, 95% CIÂ =Â 1.02-1.29).ConclusionHip arthroplasty was strongly influenced by genetic factors whereas knee arthroplasty to a greater extent depended on a high BMI. The study may imply there is a greater potential for preventing progression of knee OA to arthroplasty in comparison with hip OA.
Journal: Osteoarthritis and Cartilage - Volume 25, Issue 6, June 2017, Pages 878-884