کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5669391 | 1407960 | 2017 | 10 صفحه PDF | دانلود رایگان |
SummaryObjectiveChronic kidney disease (CKD) is characterized by metabolic disturbances in calcium and phosphorus homeostasis as kidney function declines. Alterations in blood perfusion in bone resulting from arteriosclerosis of bone vessels may relate to the progression of CKD. Herein, change in dynamic contrast enhanced (DCE) MRI parameters (A: amplitude, kel: elimination constant, and kep: permeability rate constant) and MRI T2â relaxation time of the knee cartilage were measured in a rodent nephrectomy model in order to (1) examine the relationship of peripheral blood perfusion to CKD and (2) demonstrate the feasibility of using DCE-MRI parameters and MRI T2â as imaging biomarkers to monitor disease progression.DesignTwo groups of male Sprague-Dawley rats received either (1) no intervention or (2) 5/6 nephrectomy.ResultsWe found that the CKD group (compared with the control group) had lower A and kel values and similar kep value in the lateral and medial articular cartilages beginning at 12 weeks (PÂ <Â 0.05); statistically significantly higher T2â values in the lateral and medial articular cartilages beginning at 18 weeks (PÂ <Â 0.05); statistically significantly decreased inner luminal diameter of the popliteal artery, and altered structure of the lateral and medial articular cartilages (PÂ <Â 0.05).ConclusionPerfusion deficiency and CKD may be related. DCE parameters and MRI T2â could serve as imaging biomarkers of cartilage degeneration in CKD progression.
Journal: Osteoarthritis and Cartilage - Volume 25, Issue 6, June 2017, Pages 976-985