کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5671607 1408062 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Use of nebulized antimicrobials for the treatment of respiratory infections in invasively mechanically ventilated adults: a position paper from the European Society of Clinical Microbiology and Infectious Diseases
ترجمه فارسی عنوان
استفاده از ضد میکروبی های ضد انفجار برای درمان عفونت های تنفسی در بزرگسالان تهدید شده به وسیله مهاجم مکانیکی: یک مقاله مقدماتی از انجمن بین المللی میکروبیولوژی بالینی و بیماری های عفونی
کلمات کلیدی
آمینوگلیکوزید، ضدعفونی کننده آنتی بیوتیک، کولیستین، ارگانیسم های مقاوم در برابر چندین رژیم، پنومونی بیمارستانی، مسائل مقرراتی پنومونی مرتبط با ونتیلاتور، تراکئو برونشیت مرتبط با ونتیلاتور،
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
چکیده انگلیسی

With an established role in cystic fibrosis and bronchiectasis, nebulized antibiotics are increasingly being used to treat respiratory infections in critically ill invasively mechanically ventilated adult patients. Although there is limited evidence describing their efficacy and safety, in an era when there is a need for new strategies to enhance antibiotic effectiveness because of a shortage of new agents and increases in antibiotic resistance, the potential of nebulization of antibiotics to optimize therapy is considered of high interest, particularly in patients infected with multidrug-resistant pathogens. This Position Paper of the European Society of Clinical Microbiology and Infectious Diseases provides recommendations based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology regarding the use of nebulized antibiotics in invasively mechanically ventilated adults, based on a systematic review and meta-analysis of the existing literature (last search July 2016). Overall, the panel recommends avoiding the use of nebulized antibiotics in clinical practice, due to a weak level of evidence of their efficacy and the high potential for underestimated risks of adverse events (particularly, respiratory complications). Higher-quality evidence is urgently needed to inform clinical practice. Priorities of future research are detailed in the second part of the Position Paper as guidance for researchers in this field. In particular, the panel identified an urgent need for randomized clinical trials of nebulized antibiotic therapy as part of a substitution approach to treatment of pneumonia due to multidrug-resistant pathogens.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 23, Issue 9, September 2017, Pages 629-639
نویسندگان
, , , , , , , , , , , , , , ,