کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5673564 | 1593678 | 2017 | 8 صفحه PDF | دانلود رایگان |
- Pulmonary hemorrhage was observed only in male hamsters upon Leptospira infection.
- No leptospiral DNA was detected in the lung tissues when hemorrhage was observed.
- The upregulation of nos in the hamsters without pulmonary hemorrhage was observed.
Leptospirosis causes severe clinical signs more frequently in men than in women, but the mechanism underlying the gender differences in leptospirosis remains unclear. In this study, petechial hemorrhage was observed in male but not in female hamster lung tissues infected with Leptospira interrogans serovar Hebdomadis at 120Â h pi, demonstrating that male hamsters were more susceptible to the development of a severe disease upon Leptospira infection. No leptospiral DNA was detected in the lung tissues at 120Â h pi when pulmonary hemorrhage was observed, indicating that pulmonary hemorrhage is attributable to the immune reactions of the host rather than from the direct effect of leptospires. The upregulation of nitric oxide synthase genes in the hamsters without pulmonary hemorrhage, inos and enos in female hamsters at 96Â h pi and enos in male animals without hemorrhage at 120Â h pi, may suggest that nitric oxide has a suppressive effect on leptospirosis-associated pulmonary hemorrhage.
Journal: Microbial Pathogenesis - Volume 111, October 2017, Pages 33-40