کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5674688 | 1408252 | 2017 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Th2 and Th1 Responses: Clear and Hidden Sides of Immunity Against Intestinal Helminths
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
انگل شناسی
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چکیده انگلیسی
Intestinal helminthiases affect millions of people worldwide, mainly in developing regions, where they cause a significant negative impact on human health and socioeconomic growth of affected populations. However, intestinal helminthiases are still among the most neglected tropical diseases. Protective immunity against intestinal helminths is associated with development of type 2 responses. Nevertheless, in some host-intestinal helminth combinations, local Th1 responses are initiated, inducing chronicity. The usage of helminth-mouse models is useful for elucidating the mechanisms behind the initiation of each type of response. Herein, the current knowledge on these topics is reviewed, paying particular attention to the earliest events of the immune cascade which eventually lead to either susceptibility or resistance to infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Parasitology - Volume 33, Issue 9, September 2017, Pages 678-693
Journal: Trends in Parasitology - Volume 33, Issue 9, September 2017, Pages 678-693
نویسندگان
Alba Cortés, Carla Muñoz-Antoli, J. Guillermo Esteban, Rafael Toledo,