کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5674822 1594204 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Soybean-derived Bowman-Birk inhibitor (BBI) blocks HIV entry into macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Soybean-derived Bowman-Birk inhibitor (BBI) blocks HIV entry into macrophages
چکیده انگلیسی


- BBI blocks HIV entry into macrophages.
- BBI down-regulates the expression of CD4 and CCR5.
- BBI up-regulates CC chemokines expression.

Bowman-Birk inhibitor (BBI) is a soybean-derived protease inhibitor that has anti-inflammation and anti-HIV effect. Here, we further investigated the anti-HIV action of BBI in macrophages, focusing on its effect on viral entry. We found that BBI could significantly block HIV entry into macrophages. Investigation of the mechanism(s) of the BBI action on HIV inhibition showed that BBI down-regulated the expression of CD4 receptor (as much as 80%) and induced the production of the CC chemokines (up to 60 folds at protein level) in macrophages. This inhibitory effect of BBI on HIV entry could be blocked by the neutralization antibodies to CC chemokines. These findings indicate that BBI may have therapeutic potential as a viral entry inhibitor for the prevention and treatment of HIV infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 513, 1 January 2018, Pages 91-97
نویسندگان
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