کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5674910 | 1594206 | 2017 | 7 صفحه PDF | دانلود رایگان |
- The neurotropic virus JHMV infects and kills mouse post-natal neural progenitor cells (NPCs).
- This study examines if JHMV infects mouse inducible pluripotent stem cell-derived NPCs.
- iPSC-NPCs are less susceptible to infection with JHMV and subsequent lytic effects.
The present study examines the susceptibility of mouse induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) to infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV). Similar to NPCs derived from striatum of day 1 postnatal GFP-transgenic mice (GFP-NPCs), iPSC-derived NPCs (iPSC-NPCs) are able to differentiate into terminal neural cell types and express MHC class I and II in response to IFN-γ treatment. However, in contrast to postnatally-derived NPCs, iPSC-NPCs express low levels of carcinoembryonic antigen-cell adhesion molecule 1a (CEACAM1a), the surface receptor for JHMV, and are less susceptible to infection and virus-induced cytopathic effects. The relevance of this in terms of therapeutic application of NPCs resistant to viral infection is discussed.
Journal: Virology - Volume 511, November 2017, Pages 49-55