کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5675126 1594217 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proteomic analysis of the gamma human papillomavirus type 197 E6 and E7 associated cellular proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Proteomic analysis of the gamma human papillomavirus type 197 E6 and E7 associated cellular proteins
چکیده انگلیسی


- HPV197 is a gamma genus HPV that has been detected in human skin cancers.
- We investigated HPV197 E6 and E7 cellular interactomes.
- HPV197 E6 and E7 bind important cellular targets of cancer associated HPV E6 and E7.

Gamma HPV197 was the most frequently identified HPV when human skin cancer specimens were analyzed by deep sequencing (Arroyo Muhr et al., Int. J. Cancer 136: 2546-55, 2015). To gain insight into the biological activities of HPV197, we investigated the cellular interactomes of HPV197 E6 and E7. HPV197 E6 protein interacts with a broad spectrum of cellular LXXLL domain proteins, including UBE3A and MAML1. HPV197 E6 also binds and inhibits the TP53 tumor suppressor and interacts with the CCR4-NOT ubiquitin ligase and deadenylation complex. Despite lacking a canonical retinoblastoma (RB1) tumor suppressor binding site, HPV197 E7 binds RB1 and activates E2F transcription. Hence, HPV197 E6 and E7 proteins interact with a similar set of cellular proteins as E6 and E7 proteins encoded by HPVs that have been linked to human carcinogenesis and/or have transforming activities in vitro.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 500, January 2017, Pages 71-81
نویسندگان
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