کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5675322 1594322 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HPV-transgenic mouse models: Tools for studying the cancer-associated immune response
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
HPV-transgenic mouse models: Tools for studying the cancer-associated immune response
چکیده انگلیسی


- There are varied types of mouse models (e.g. spontaneous, transgenic).
- Different models allow diverse study approaches.
- Recent models display good characteristics for scientific research.
- New models should focus on the mechanisms behind the virus-immune system relation.

For decades, research on the pathogenesis of papillomavirus-induced lesions, particularly of human papillomavirus (HPV) has relied on the use of animal models. Among these, HPV-transgenic mice are some of the most frequently employed. After some initial unsuccessful attempts, researchers have succeeded in targeting the expression of one or more HPV-16 oncogenes to squamous epithelia, closely mimicking the lesions observed in cancer patients. The present review describes the relevance and usefulness of these animal models in understanding the tumour-associated immune response and developing new preventive and therapeutic strategies for HPV-associated cancers. In particular, this review details the importance of transgenic mice for dissecting and modulating relevant aspects of the tumour-associated immune response. Other animal models for studying papillomaviral diseases are briefly mentioned, along with their respective advantages and limitations. HPV-transgenic mouse strains remain reliable, versatile and commodious, even if perhaps underestimated, animal models for studying HPV-induced multi-step carcinogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 235, 2 May 2017, Pages 49-57
نویسندگان
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