کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5685334 | 1598222 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fractures and Osteomalacia in a Patient Treated With Frequent Home Hemodialysis
ترجمه فارسی عنوان
شکستگی و استئومالاسیا در یک بیمار درمان شده با همودیالیز خانگی مکرر
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
osteomalaciaend-stage renal disease (ESRD) - بیماری کلیوی مرحله پایانی (ESRD)Bone biopsy - بیوپسی استخوانBone fracture - شکستگی استخوانfibroblast growth factor 23 (FGF-23) - فاکتور رشد فیبروبلاست 23 (FGF-23)serum phosphate - فسفات سرمhome hemodialysis - همودیالیز خانهfrequent hemodialysis - همودیالیز مکررHypophosphatemia - هیپوفسفاتمیCase report - گزارش موردی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
چکیده انگلیسی
Bone deformities and fractures are common consequences of renal osteodystrophy in the dialysis population. Persistent hypophosphatemia may be observed with more frequent home hemodialysis regimens, but the specific effects on the skeleton are unknown. We present a patient with end-stage renal disease treated with frequent home hemodialysis who developed severe bone pain and multiple fractures, including a hip fracture and a tibia-fibula fracture complicated by nonunion, rendering her nonambulatory and wheelchair bound for more than a year. A bone biopsy revealed severe osteomalacia, likely secondary to chronic hypophosphatemia and hypocalcemia. Treatment changes included the addition of phosphate to the dialysate, a higher dialysate calcium concentration, and increased calcitriol dose. Several months later, the patient no longer required a wheelchair and was able to ambulate without pain. Repeat bone biopsy revealed marked improvements in bone mineralization and turnover parameters. Also, with increased dialysate phosphate and calcium concentrations, as well as increased calcitriol, circulating fibroblast growth factor 23 levels increased.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 70, Issue 3, September 2017, Pages 445-448
Journal: American Journal of Kidney Diseases - Volume 70, Issue 3, September 2017, Pages 445-448
نویسندگان
Mark R. MD, MS, Larry MD, Barbara RN, Harald MD, Isidro B. MD,