Inter-observer Variability of Prostate Delineation on Cone Beam Computerised Tomography Images

Expert observers had difficulty agreeing upon the location of the prostate peri-prostatic interface on the images provided. The effect on the centre of mass determination was small, and inter-observer variability for prostate detection on cone beam computerised tomography images is not prohibitive to the use of soft tissue guidance protocols. Potential exists for significant systematic matching errors, and points to the need for rigorous therapist image recognition training and development of guidance protocols before clinical implementation of soft tissue cone beam image guidance.