Immunohistochemical expression of p53 and c-Myc at the invasive front of oral squamous cell carcinoma and its relation with clinicopathologic characteristics

- p53 at the ITF of OSCC may be supplemental in assessing tumor cell characteristics.
- Mutant p53 perhaps shows the most anaplastic fields in the invasive area
- c-Myc may facilitate loss of differentiation, aggressiveness and invasive growth.
- Overexpression of c-Myc along with p53 may cause a rapid progression of the OSCC