کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5718949 | 1607410 | 2017 | 6 صفحه PDF | دانلود رایگان |
ObjectivesTo clarify the occurrence of cardiac events based on the maximal diameter of the maximal coronary artery aneurysm (CAA) in Kawasaki disease (KD).Study designTwo hundred fourteen patients (160 male and 54 female) who had had at least 1 CAA in the selective coronary angiogram less than 100 days after the onset of KD were studied. We measured the maximal CAA diameters in the major branches of the initial coronary angiograms. Death, myocardial infarction and coronary artery revascularization were included as cardiac events in this study. We divided the patients into three groups based on the maximal CAA diameter (large â¥8.0âmm; medium â¥6.0âmm and <8.0âmm; small <6.0âmm). Further, we also analyzed the cardiac events based on laterality of maximal CAA (bilateral, unilateral) and body surface area (BSA).ResultsCardiac events occurred in 44 patients (21%). For BSAâ<â0.50âm2, the 30-year cardiac event-free survival in the large and medium groups was 66% (nâ=â38, 95% CI, 49-80) and 62% (nâ=â27, 95% CI, 38-81), respectively. For BSAââ¥â0.50âm2, that in large group was 54% (nâ=â58, 95% CI, 40-67). There were no cardiac events in the medium group for BSA â¥0.50âm2 (nâ=â36) and the small group (nâ=â56). In the large analyzed group, the 30-year cardiac event-free survival in the bilateral and unilateral groups was 40% (nâ=â48, 95% CI, 27-55) and 78% (nâ=â48, 95% CI, 63-89), respectively (Pâ<â.0001).ConclusionsThe group with the highest risk of cardiac events was the patient group with the maximal CAA diameter â¥6.0âmm with BSAâ<â0.50âm2 and the maximal CAA diameter â¥8.0âmm with BSAââ¥â0.50âm2. At 30 years after the onset of KD, cardiac event-free survival was about 60%. Given the high rate of cardiac events in this patient population, life-long cardiovascular surveillance is advised.
Journal: The Journal of Pediatrics - Volume 188, September 2017, Pages 70-74.e1