کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5726105 1609735 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of fractional anisotropy facilitates differentiation of glioblastoma and brain metastases in a clinical setting
ترجمه فارسی عنوان
تجزیه و تحلیل آنیزوتروپیک کریستالی تمایز گلیوبلاستوما و متاستاز مغز را در محیط بالینی تسهیل می کند
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی رادیولوژی و تصویربرداری
چکیده انگلیسی

PurposeDifferentiating glioblastoma from brain metastases is important for therapy planning. Diffusion tensor imaging (DTI) was described as a promising tool, however with conflicting results.Aimof this study was to analyze the clinical utility of DTI for the differentiation of brain metastases and glioblastoma.Methods294 patients (165 glioblastoma, 129 brain metastases) with preoperative DTI were included in this retrospective study. Fractional anisotropy (FA) was measured via regions of interest (ROIs) in the contrast-enhancing tumor, the necrosis and the FLAIR-hyperintense non-enhancing peritumoral region (NEPTR). Two neuroradiologists classified patient cases as glioblastoma or brain metastases without and with knowledge of FA values.ResultsGlioblastoma showed significantly higher FAcontrast (median glioblastoma = 0.33, metastases = 0.23; P < 0.001) whereas no significant difference was observed for FANEPTR (0.21 vs. 0.22; P = 0.28) and for FAnecrosis (0.17 vs. 0.18, P = 0.37). FA improved diagnostic accuracy of the neuroradiologists significantly from an AUC of 0.84/0.85 (Reader1/Reader2) to 0.89/0.92.ConclusionsGlioblastoma show significantly higher FA values in the contrast enhancing tumor part than brain metastases. Implementation of a ROI-based measurement of FA values and FA color maps in clinical routine helps to differentiate between glioblastoma and brain metastases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Radiology - Volume 85, Issue 12, December 2016, Pages 2182-2187
نویسندگان
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