کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5731705 | 1611930 | 2017 | 12 صفحه PDF | دانلود رایگان |
- To perform a meta-analysis to investigate the impact of acetaminophen for pain management after TJA.
- Intravenous acetaminophen to multimodal analgesia could significantly reduce pain after TJA.
BackgroundThis meta-analysis aimed to perform a meta-analysis to investigate the impact of additional intravenous acetaminophen for pain management after total joint arthroplasty (TJA).MethodsWe conducted electronic searches of Medline (1966-2017.07), PubMed (1966-2017.07), Embase (1980-2017.07), ScienceDirect (1985-2017.07) and the Cochrane Library. Randomized controlled trials (RCTs) and non-RCTs were included. The quality assessments were performed according to the Cochrane systematic review method. The primary outcomes were postoperative pain scores and opioid consumption. Meta-analysis was performed using Stata 11.0 software.ResultsA total of four studies were retrieved involving 865 participants. The present meta-analysis indicated that there were significant differences between groups in terms of pain scores at POD 1 (WMD = â0.954, 95% CI: â1.204 to â0.703, P = 0.000), POD 2 (WMD = â1.072, 95% CI: â2.072 to â0.073, P = 0.000), and POD 3 (WMD = â0.883, 95% CI: â1.142 to â0.624, P = 0.000). Significant differences were found regarding opioid consumption at POD 1 (WMD = â3.144, 95% CI: â4.142 to â2.146, P = 0.000), POD 2 (WMD = â5.665, 95% CI: â7.383 to â3.947, P = 0.000), and POD 3 (WMD = â3.563, 95% CI: â6.136 to â0.991, P = 0.007).ConclusionAdditional intravenous acetaminophen to multimodal analgesia could significantly reduce pain and opioid consumption after total joint arthroplasty with fewer adverse effects. Higher quality RCTs are required for further research.
Journal: International Journal of Surgery - Volume 47, November 2017, Pages 135-146