کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5732576 | 1612084 | 2017 | 4 صفحه PDF | دانلود رایگان |
- Malignant mesothelioma is a rare neoplasm of mesothelial cells.
- It occurs mostly in the pleura or peritoneum and less frequently in the liver.
- Primary intrahepatic mesothelioma is not in the WHO classification of hepatic tumors.
- Mesothelioma is more common in men with a mean age of 58 years.
- We present a rare case of primary liver malignant mesothelioma in a young female.
IntroductionMalignant mesothelioma is a rare neoplasm of mesothelial cells arising most frequently in the pleura or peritoneum and less frequently in the liver.Case presentationWe present a case of primary hepatic mesothelioma of 41Â year old woman. She had no history of asbestos exposure or cancer. Abdominal computed tomography (CT) showed 21Â cm intrahepatic mass in the right lobe with many cystic lesions and few small calcifications. Pathology showed a biphasic cellular pattern. In addition, the tumor cells were positive for Calretinin, Creatine Kinase (CK)5/6, CK7, CKAEI 1/3, Wilms Tumor protein (WT-1), and Vimentin, but were negative for Alpha Feto protein (AFP), Thrombotic Thrombocytopenic Purpura (TTP-1), Anti-Hepatocyte Specific Antigen (HSA), Synaptophysin, CK20, and Homeobox protein (CDx-2).DiscussionPrimary intrahepatic mesothelioma (PIHMM) is not included in the classification of the World Health Organization classification of hepatic tumors. Mesothelial cells are not normally found in the liver, but some reported cases suggest it may grow from the mesothelial cells of the Glisson's capsule.ConclusionThe probability of hepatic mesothelioma should not be ruled out, even in a young woman without a clear history of asbestos exposure.
Journal: International Journal of Surgery Case Reports - Volume 30, 2017, Pages 58-61