کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5736960 1614501 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases
ترجمه فارسی عنوان
اختلال اندو لیسوزومی: یک مکانیزم همگرا در بیماری های نوروژنیک
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Multiple genes for AD, PD and FTD are involved in the endo-lysosomal pathways.
- Dysfunction of endo-lysosomal pathways impairs degradation of pathogenic proteins.
- Key components in the endo-lysosomal machinery may be therapeutic targets.

Endo-lysosomal pathways are essential in maintaining protein homeostasis in the cell. Numerous genes in the endo-lysosomal pathways have been found to associate with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia (FTD). Mutations of these genes lead to dysfunction in multiple steps of the endo-lysosomal network: autophagy, endocytic trafficking and lysosomal degradation, resulting in accumulation of pathogenic proteins. Although the exact pathogenic mechanism varies for different disease-associated genes, dysfunction of the endo-lysosomal pathways represents a converging mechanism shared by these diseases. Therefore, strategies that correct or compensate for endo-lysosomal dysfunction may be promising therapeutic approaches to treat neurodegenerative diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Neurobiology - Volume 48, February 2018, Pages 52-58
نویسندگان
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