کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737934 | 1614729 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Klotho regulates CA1 hippocampal synaptic plasticity
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کلمات کلیدی
PPFMAP2SECAMPAfEPSPMK-801NMDAEPSC - EPSCoRI/O - I / Opaired-pulse facilitation - تسکین زوایای پالسیlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP excitatory post-synaptic current - جریان پسا سیناپتی هیجان انگیزMin - حداقلminute - دقیقهSecond - دومینWild-type mouse - ماوس نوعی وحشیmillisecond - میلی ثانیهmilliliter - میلی لیترmillivolt - میلیوولتHertz - هرتزinput/output - ورودی خروجیfield excitatory post-synaptic potential - پتانسیل پس از سیناپسی مزمن تحریک پذیرMicrotubule associated protein 2 - پروتئین مرتبط با میکروتوبول 2Synaptic plasticity - پلاستیسیته سیناپسیBrain aging - پیری مغزیKlotho - کلوتو
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Global klotho overexpression extends lifespan while global klotho-deficiency shortens it. As well, klotho protein manipulations inversely regulate cognitive function. Mice without klotho develop rapid onset cognitive impairment before they are 2Â months old. Meanwhile, adult mice overexpressing klotho show enhanced cognitive function, particularly in hippocampal-dependent tasks. The cognitive enhancing effects of klotho extend to humans with a klotho polymorphism that increases circulating klotho and executive function. To affect cognitive function, klotho could act in or on the synapse to modulate synaptic transmission or plasticity. However, it is not yet known if klotho is located at synapses, and little is known about its effects on synaptic function. To test this, we fractionated hippocampi and detected klotho expression in both pre and post-synaptic compartments. We find that loss of klotho enhances both pre and post-synaptic measures of CA1 hippocampal synaptic plasticity at 5Â weeks of age. However, a rapid loss of synaptic enhancement occurs such that by 7Â weeks, when mice are cognitively impaired, there is no difference from wild-type controls. Klotho overexpressing mice show no early life effects on synaptic plasticity, but decreased CA1 hippocampal long-term potentiation was measured at 6Â months of age. Together these data suggest that klotho affects cognition, at least in part, by regulating hippocampal synaptic plasticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 347, 7 April 2017, Pages 123-133
Journal: Neuroscience - Volume 347, 7 April 2017, Pages 123-133
نویسندگان
Qin Li, Hai T. Vo, Jing Wang, Stephanie Fox-Quick, Lynn E. Dobrunz, Gwendalyn D. King,