کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738036 1615037 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparative connectomics: Mapping the inter-individual variability of connections within the regions of the human brain
ترجمه فارسی عنوان
لینکدانی مقایسه: نقشه برداری تنوع بین فردی ارتباطات درون مناطق مغز انسان
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
The human braingraph, or connectome is a description of the connections of the brain: the nodes of the graph correspond to small areas of the gray matter, and two nodes are connected by an edge if a diffusion MRI-based workflow finds fibers between those brain areas. We have constructed 1015-vertex graphs from the diffusion MRI brain images of 392 human subjects and compared the individual graphs with respect to several different areas of the brain. The inter-individual variability of the graphs within different brain regions was discovered and described. We have found that the frontal and the limbic lobes are more conservative, while the edges in the temporal and occipital lobes are more diverse. Interestingly, a “hybrid” conservative and diverse distribution was found in the paracentral lobule and the fusiform gyrus. Smaller cortical areas were also evaluated: precentral gyri were found to be more conservative, and the postcentral and the superior temporal gyri to be very diverse. Similar studies concerning the human genome discovered more and less conservative sections of the DNA, opening up entirely new fields in genomics. We think that the present study is the first step in this direction in human connectomics. The clinical significance of the conservativity of a given cerebral area could be the higher sensitivity for traumas and developmental or neuro-degenerative events than the less conservative areas.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 662, 1 January 2018, Pages 17-21
نویسندگان
, , , ,