کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738139 1615046 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Precuneus degeneration and isolated apathy in patients with Parkinson's disease
ترجمه فارسی عنوان
دژنراسیون دفاعی و بی کفایتی در بیماران مبتلا به بیماری پارکینسون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- PD patients with isolated apathy showed attentive and working memory dysfunctions.
- Hypometabolism and atrophy in the Precuneus is correlated with apathy severity.
- Precuneus degeneration can be one of neural substrates to isolated apathy in PD.

IntroductionTo investigate isolated apathy in a set of consecutively enrolled Parkinson's disease (PD) patients without dementia, depression, and significant motor response fluctuations, by conducting neuropsychological and neuroimaging analyses.MethodsOne hundred twenty-four patients were eligible for inclusion in this study. Clinical information and data were collected from a predefined neuropsychological test battery, including the mini-mental status examination, apathy scale, geriatric depression scale, digit span test, Boston naming test, Seoul verbal learning test, controlled oral word association test, go-no-go test, and the Rey figure copy test. From matched groups of 10 non-apathetic and 12 apathetic patients in the initial cohort and 9 healthy controls, [18F]fluorodeoxyglucose positron emission tomography and volumetric magnetic resonance images were acquired.ResultsApathy was detected in 59.7% of the initial cohort. Apathetic patients had lower scores in the digit span forward, digit span backward, and immediate recall of verbal learning tests than did those without apathy (p < 0.05). The results were unaffected by parkinsonian motor severity and medication dose. Neuroimaging analyses revealed precuneus atrophy and hypometabolism in patients with isolated apathy. These precuneus changes were well-correlated with apathy severity (p < 0.001). Apathy severity was also positively correlated with gray matter volume in the superior frontal gyrus and cerebellar vermis, and with metabolism in the medial frontal and anterior cingulate regions (p < 0.001).ConclusionsPD patients with isolated apathy showed attention and working memory dysfunction, and precuneus degeneration might be related to this distinctive nonmotor symptom in PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 653, 13 July 2017, Pages 250-257
نویسندگان
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