کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738540 1615039 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research articleIntranasal insulin treatment alleviates methamphetamine induced anxiety-like behavior and neuroinflammation
ترجمه فارسی عنوان
مقاله پژوهشی درمان انسولین غیرطبیعی باعث کاهش رفتار اضطراب ناشی از متامفتامین و التهاب عصبی می شود
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Repeated methamphetamine exposure induced an anxiety-like behavior.
- Repeated methamphetamine exposure increased neuroinflammatory factors.
- Intranasal insulin treatment alleviated MA-induced anxiety and neuroinflammation.

Insulin, as a peptide hormone, has recently gained attention for its pro-cognitive, anti-inflammatory and neuroprotective effects in the central nervous system (CNS). Most studies have indicated anxiogenic and neuroinflammatory effects of methamphetamine (MA) and other psychostimulants, even after periods of abstinence. The present study aimed to examine whether intranasal (IN) insulin treatment with high CNS bioavailability and minimal systemic side effects, can reverse the anxiety-like behavior and neuroinflammation induced by repeated MA administration. In male wistar rats, escalating doses of MA (1-10 mg/kg, i.p.) were administrated twice a day for 10 consecutive days. IN insulin treatment (0.5 IU/day, for 7 days after MA discontinuation) attenuated MA-induced anxiety-like behavior in the elevated plus maze task, and significantly decreased the levels of glial cell markers (GFAP and Iba1), pro-inflammatory cytokines (TNF-α and IL-6) as well as COX2 and NF-κB players of neuroinflammation, in the hippocampus of MA-treated animals. These findings introduce insulin as a potential therapeutic approach for the treatment of MA aversive symptoms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 660, 1 November 2017, Pages 122-129
نویسندگان
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