کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5738624 | 1615045 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Noxious, but not innocuous, thermal stimuli evoke pERK expression in dorsal horn neurons after spared nerve injury in adult rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Noxious stimulation of sensory afferents evokes phosphorylated extracellular signal regulated kinase (pERK) expression in spinal cord neurons. This study investigated the expression of pERK in the dorsal horn neurons in response to innocuous and noxious cold stimuli in naïve versus spared nerve injury (SNI) rats. Noxious cold or hot stimuli (0 or 45 °C) elicited pERK expression in laminae I-II whereas cooling stimuli from 32 °C to 25, 15 or 5 °C produced no or little pERK expression in dorsal horn neurons. Five days after SNI, a time when these animals showed heat hyperalgesia, cold and mechanical hypersensitivity, only noxious heat stimuli produced a significant increase in pERK expression compared to naïve rats in spinal cord neurons. Thus, pERK cannot be used as an activity marker for neurons responding to cooling stimuli or cold allodynia; however, these results confirm the role of pERK as an activity marker for heat hyperalgesia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 654, 27 July 2017, Pages 49-55
Journal: Neuroscience Letters - Volume 654, 27 July 2017, Pages 49-55
نویسندگان
Mohamad S. Samour, Sumaiya M. Shaikh, David A. Mahns, Peter J. Shortland,