کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738823 1615059 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research articleRegional and subcellular distribution of GABAC ρ3 receptor in brain of R6/2 mouse model of Huntington's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Research articleRegional and subcellular distribution of GABAC ρ3 receptor in brain of R6/2 mouse model of Huntington's disease
چکیده انگلیسی


- GABAC ρ3 expression decreases in the cortex, striatum and hippocampus of HD tg mouse brain.
- Loss of GABAc ρ3 receptor immunoreactivity may account for diminished inhibitory input and neurodegeneration in HD.
- Activation of GABARs and inhibition of glutamatergic pathway might protect neuronal loss in HD.

In the present study, we describe the distribution of GABAC ρ3 receptor immunoreactivity in the cortex, striatum and hippocampus of wild type (wt) and 11 weeks old HD transgenic (tg) R6/2 mouse brain. In the brain of wt mice, GABAC ρ3 immunoreactivity is well expressed in neuronal cells, nerve fibers and axonal processes. In comparison to wt, GABAC ρ3 receptor like immunoreactivity decreases significantly in all three brain regions of R6/2 mice. The altered distributional pattern and significant changes in GABAC ρ3 receptor immunoreactivity as seen in the R6/2 mouse brain might be a plausible molecular mechanism for excitotoxicity in HD pathogenesis due to the loss of inhibitory input.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 640, 15 February 2017, Pages 81-87
نویسندگان
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