کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5748472 1619032 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood
چکیده انگلیسی


- Examined sensitive windows of prenatal PM2.5 exposure on mtDNA in cord blood
- Sensitive window identified at gestational weeks 35-40
- Higher PM2.5 during sensitive window associated with lower mtDNA content
- Findings suggest sex-specific associations.

IntroductionChanges in mitochondrial DNA (mtDNA) can serve as a marker of cumulative oxidative stress (OS) due to the mitochondria's unique genome and relative lack of repair systems. In utero particulate matter ≤ 2.5 μm (PM2.5) exposure can enhance oxidative stress. Our objective was to identify sensitive windows to predict mtDNA damage experienced in the prenatal period due to PM2.5 exposure using mtDNA content measured in cord blood.Material and methodsWomen affiliated with the Mexican social security system were recruited during pregnancy in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) study. Mothers with cord blood collected at delivery and complete covariate data were included (n = 456). Mothers' prenatal daily exposure to PM2.5 was estimated using a satellite-based spatio-temporally resolved prediction model and place of residence during pregnancy. DNA was extracted from umbilical cord leukocytes. Quantitative real-time polymerase chain reaction (qPCR) was used to determine mtDNA content. A distributive lag regression model (DLM) incorporating weekly averages of daily PM2.5 predictions was constructed to plot the association between exposure and OS over the length of pregnancy.ResultsIn models that included child's sex, mother's age at delivery, prenatal environmental tobacco smoke exposure, birth year, maternal education, and assay batch, we found significant associations between higher PM2.5 exposure during late pregnancy (35-40 weeks) and lower mtDNA content in cord blood.ConclusionsIncreased PM2.5 during a specific prenatal window in the third trimester was associated with decreased mtDNA content suggesting heightened sensitivity to PM-induced OS during this life stage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environment International - Volume 98, January 2017, Pages 198-203
نویسندگان
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