کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5749657 | 1412483 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pressurized hot water extraction of 10-deacetylbaccatin III from yew for industrial application
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study a systematic and model-based approach for a process development focusing on pressurized hot water extraction (PHWE) is investigated, considering potential thermal degradation of high-value compounds. For extraction of 10-deacetylbaccatin III (10-DAB) from yew as a representative test system, water at 120â°C provided the best compromise between extraction yield and thermal degradation. A yield of almost 100% with regard to the overall amount of 10-DAB was reached in only 20âmin. Each experiment for model parameter determination was carried out with 1.9âg of plant material at a flowrate of 1âmL/min and an applied pressure of 11âbar. All experimental values are assessed by a physico-chemical (rigorous) extraction model with experimental values and simulation results showing high conformity. In order to demonstrate the usability of the extraction model and model parameter determination a scale-up prediction was calculated. The scale-up experiments were predicted precisely and thus the model validated. The experiments and the simulation results for a column with a volume of 104âmL and a mass of 22âg yew needles were consistent with the milli-scale used for model parameter determination.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Resource-Efficient Technologies - Volume 3, Issue 2, June 2017, Pages 177-186
Journal: Resource-Efficient Technologies - Volume 3, Issue 2, June 2017, Pages 177-186
نویسندگان
Maximilian Sixt, Jochen Strube,