کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5802392 | 1555666 | 2015 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro effects of Eucalyptus staigeriana nanoemulsion on Haemonchus contortus and toxicity in rodents
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
Strategies for controlling gastrointestinal nematodes have been developed based on the use of numerous alternative methods, including the use of phytotherapy. New formulations of essential oils with anthelmintic activity have been proposed as a means to optimize their biological effects. Thus, the objective of this study was to formulate a nanoemulsion to optimize the nematicide effect of Eucalyptus staigeriana essential oil (EsEO). Initially, physico-chemical analyses were performed to verify the stability of the E. staigeriana nanoemulsion (EsNano). In vitro tests were conducted to evaluate the ovicidal and larvicidal activities of both EsNano and EsEO against Haemonchus contortus, and toxicology tests were then performed on rodents. The EsEO content in the nanoemulsion was 36.4% (v/v), and the mean particle size was 274.3Â nm. EsNano and EsEO inhibited larval hatching by 99% and 96.3% at 1 and 2Â mg/ml concentrations, respectively, and inhibited larval development by 96.3% and 97.3% at 8Â mg/ml concentrations. The acute toxicity test revealed that the EsNano and EsEO doses required to kill 50% of the mice (LD50) were 1,603.9 and 3,495.9Â mg/ml, respectively. EsNano did not alter the hematological parameters in the rats after treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Parasitology - Volume 212, Issues 3â4, 15 September 2015, Pages 444-447
Journal: Veterinary Parasitology - Volume 212, Issues 3â4, 15 September 2015, Pages 444-447
نویسندگان
Wesley Lyeverton Correia Ribeiro, Ana Lourdes Fernandes Camurça-Vasconcelos, Iara Tersia Freitas Macedo, Jessica Maria Leite dos Santos, José Vilemar de Araújo-Filho, Juliana de Carvalho Ribeiro, Vanessa de Abreu Pereira, Daniel de Araújo Viana,