کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5825856 | 1558119 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
YAP/TAZ as therapeutic targets in cancer
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: YAP/TAZ as therapeutic targets in cancer YAP/TAZ as therapeutic targets in cancer](/preview/png/5825856.png)
چکیده انگلیسی
The biology and regulation of YAP and TAZ, two closely related transcriptional regulators, are receiving increasing attention owing to their fundamental roles in organ growth, tissue repair and cancer. In particular, the widespread activation of YAP/TAZ in carcinomas, and the crucial role of YAP/TAZ activation for many 'hallmarks' of cancer are indicating YAP/TAZ as prime targets for designing anti-cancer drugs. Here, we start from the known modalities to regulate YAP/TAZ to highlight possible routes of therapeutic intervention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Pharmacology - Volume 29, August 2016, Pages 26-33
Journal: Current Opinion in Pharmacology - Volume 29, August 2016, Pages 26-33
نویسندگان
Francesca Zanconato, Giusy Battilana, Michelangelo Cordenonsi, Stefano Piccolo,