SIRT1 signaling as potential modulator of skeletal muscle diseases

► In skeletal muscle diseases muscles undergo atrophy or wasting. ► The NAD-dependent protein deacetylase SIRT1 exerts pleiotropic beneficial effects. ► SIRT1 ameliorates muscle function during injury and aging. ► SIRT1 activity inhibits inflammatory processes, such as in muscular dystrophy. ► SIRT1 activity governs macrophage and satellite cells functions in the muscle.