Cholesterol metabolism and colorectal cancers

► Dietary and plasma cholesterol levels are weakly associated with CRC development. ► Statin use is associated with a 10% reduction in all (unselected) CRC. ► Haplotypes of CYP7A1 (enzyme in bile acid production) are associated with CRC. ► Haplotypes of HMGCoA reductase influence CRC chemoprevention by Statins. ► Molecular features of CRC (SMAD4, KRAS) may predict sensitivity to Statins.