Regulation of cholesterol biosynthesis and cancer signaling

► Cholesterol biosynthesis is a highly conserved, from yeast to humans, metabolic pathway that is the essential for cell growth. ► Alterations in the cellular sterol pools have profound effects on endosomes trafficking. ► And also on the signaling activity of most cellular receptor systems in cancer cells. ► Specific targeting of sterol pathway enzymes or sterol binding proteins may be a powerful anticancer strategy. ► Especially given the absolute linearity and non-redundancy of the pathway.