Immunomodulatory effects of azithromycin on the establishment of lipopolysaccharide tolerance in mice

► LPS tolerance model is characterized by an M2 skewed response ► Azithromycin augmented tolerance induction to LPS. ► Azithromycin reduced serum concentrations of pro-inflammatory cytokines TNFα and CCL5. ► Concentrations of anti-inflammatory cytokines, IL-10 and IL-1ra, were unchanged following azithromycin treatment.