کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5837282 | 1123962 | 2013 | 5 صفحه PDF | دانلود رایگان |
Ethnopharmacological relevanceThe root of Panax ginseng C.A. Mey has various beneficial pharmacological effects. The present study aimed to evaluate the analgesic activities of glycoproteins from the root of Panax ginseng C.A. Mey in mice.Materials and methodsGlycoproteins were isolated and purified from the root of Panax ginseng C.A. Mey. Physicochemical properties and molecular mass were determined by chemical assay and HPLC. Acetic acid-induced writhing and hot-plate tests were employed to study the analgesic effect of glycoproteins and compared with that of aspirin or morphine. The locomotor activity was tested in mice by using actophometer.ResultsFour glycoproteins were obtained. The glycoproteins which protein content was the highest (73.04%) displayed dose-dependent analgesic effect. In writhing test, the glycoproteins significantly inhibited writhes (P<0.001) at the dose of 20Â mg/kg by intraperitoneal injection. In hot-plate test, only at the dose of 20Â mg/kg prolong the hot-plate latency (P<0.05, at 30Â min). In the locomotor activity test, the glycoproteins were significant decrease of motility counts at the dose of 20 and 40Â mg/kg.ConclusionThese findings collectively indicate that the glycoproteins from the root of Panax ginseng C.A. Mey exhibited significant analgesic activities and the proteins were the active site, providing evidence for its pharmacal use.
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Journal: Journal of Ethnopharmacology - Volume 148, Issue 3, 30 July 2013, Pages 946-950