Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants

► We review the links between endocannabinoids, depression and actions of antidepressants. ► Deficiencies in endocannabinoid signaling produce symptoms of depression. ► Facilitation of endocannabinoid signaling produces antidepressant-like effects. ► Endocannabinoids may mediate the effects of some conventional antidepressants.