کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5858431 | 1562167 | 2015 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Associations of cadmium, bisphenol A and polychlorinated biphenyl co-exposure in utero with placental gene expression and neonatal outcomes
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کلمات کلیدی
BPAIGFGnRHLRCUCBPCBsBisphenol A - بیسفنول ای، بیسفنول APolychlorinated biphenyls - بیفنیل پلیکلر Endocrine disrupting compounds - ترکیبات غشایی مصنوعیUmbilical cord blood - خون بند نافe-waste - زباله های الکترونیکیElectronic waste - ضایعات الکترونیکیInsulin-like growth factor - فاکتور رشد مانند انسولینPrenatal exposure - قرار گرفتن در معرض پیش از قاعدگیBirth outcomes - نتایج تولدgonadotropin releasing hormone - هورمون آزاد کننده گنادوتروپینCadmium - کادمیمLeptin receptor - گیرنده لپتین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In utero co-exposure to endocrine disrupting compounds can perturb fetal development. However, the effect of co-exposure on pivotal regulatory genes has seldom been investigated. We explored the effects of in utero co-exposure to cadmium (Cd), bisphenol A (BPA) and polychlorinated biphenyls (PCBs) on master regulator genes. We recruited 284 healthy pregnant women, of whom 262 provided both cord blood and placenta samples, and 200 had all measurements taken. Placental Cd, cord blood BPA and total PCBs in the exposed group were higher than a reference group. KISS1 expression level in placental tissue was threefold higher in the exposed group than in the reference, and was positively associated with all toxicants. Leptin and leptin receptor expression were also significantly higher, but were only associated with BPA. From our findings, we conclude that lower birth weight is correlated with Cd and PCBs, and may result from the increased KISS1 mRNA expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 52, April 2015, Pages 62-70
Journal: Reproductive Toxicology - Volume 52, April 2015, Pages 62-70
نویسندگان
Xijin Xu, Yin Mei Chiung, Fangfang Lu, Shaoshan Qiu, Minhui Ji, Xia Huo,