کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5860057 | 1133164 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phenylbutyric acid inhibits epithelial-mesenchymal transition during bleomycin-induced lung fibrosis
ترجمه فارسی عنوان
اسید فنیل بوتیریک انتقال پروتئین-مزانشیمال را در طی فیبروز ریوی ناشی از بلومویسین مهار می کند
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کلمات کلیدی
اسید فینیل بوتیریک، بلومایسین، استرس تناسلی اندوپلاسمی، پاسخ پروتئین باز شده، گذار اپیتلیال-مزانشیمال،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
A recent report showed that unfolded protein response (UPR) signaling was activated during bleomycin (BLM)-induced pulmonary fibrosis. Phenylbutyric acid (PBA) is an endoplasmic reticulum (ER) chemical chaperone that inhibits the UPR signaling. The present study investigated the effects of PBA on BLM-induced epithelial-mesenchymal transition (EMT) and pulmonary fibrosis. For induction of pulmonary fibrosis, all mice except controls were intratracheally injected with a single dose of BLM (3.0 mg/kg). In PBA + BLM group, mice were intraperitoneally injected with PBA (150 mg/kg) daily. Three weeks after BLM injection, EMT was measured and pulmonary fibrosis was evaluated. BLM-induced pulmonary UPR activation was inhibited by PBA. Moreover, BLM-induced pulmonary nuclear factor kappa B (NF-κB) p65 activation was blocked by PBA. In addition, BLM-induced up-regulation of pulmonary inflammatory cytokines was repressed by PBA. Further analysis showed that BLM-induced α-smooth muscle actin (α-SMA), a marker for EMT, was significantly attenuated by PBA. Moreover, BLM-induced pulmonary collagen (Col1α1 and Col1α2) was obviously inhibited by PBA. Importantly, BLM-induced pulmonary fibrosis, as determined using Sirius red staining, was obviously alleviated by PBA. Taken together, these results suggest that PBA alleviates ER stress-mediated EMT in the pathogenesis of BLM-induced pulmonary fibrosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 232, Issue 1, 5 January 2015, Pages 213-220
Journal: Toxicology Letters - Volume 232, Issue 1, 5 January 2015, Pages 213-220
نویسندگان
Hui Zhao, Hou-Ying Qin, Lin-Feng Cao, Yuan-Hua Chen, Zhu-Xia Tan, Cheng Zhang, De-Xiang Xu,