Altered plasma membrane dynamics of bone morphogenetic protein receptor type Ia in a low bone mass mouse model

► BMSCs isolated from the mouse model, B6.C3H-6T, had increased BMP receptor type Ia co-localization with caveolae. ► Decreased BMP2 signaling in BMSCs isolated from the B6.C3H-6T mice with BMP2 stimulation. ► Disruption of caveolae in BMSCs isolated from the B6.C3H-6T mice induced BMP2 signaling in the absence of BMP2.