Bronchial epithelial cells release IL-6, CXCL1 and CXCL8 upon mast cell interaction

► Co-culture of PBEC and mast cells elevates the production of IL-6, CXCL1 and CXCL8. ► MAPKs and NF-κB regulate the production of IL-6, CXCL1 and CXCL8 in co-culture. ► The interaction of PBEC with mast cells may regulate local inflammatory response.