کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5902056 | 1156841 | 2016 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Does bilirubin protect against developing diabetes mellitus?
ترجمه فارسی عنوان
آیا بیلی روبین در برابر دیابت بارداری محافظت می کند؟
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کلمات کلیدی
دیابت بیلیروبین، مطالعات آینده نگر، استرس اکسیدان تجزیه و تحلیل ژنتیکی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
After 25Â years of evaluating bilirubin as a possible protective agent in neonatal and cardiovascular disease, interest has moved on to a exploring a possible protective role in diabetes mellitus (DM). This review finds conflicting prospective data for a protective relationship though there are retrospective, case-controlled data, that can only show association, which is not causality. Only prospective studies can show causality. Also, it would appear that the underlying biochemical assumptions do not readily translate from the animal to the human setting. Given that many factors impact on circulating bilirubin levels, it is not surprising that a clear-cut answer is not available; the jury is still out. Any relationship between DM and bilirubin might relate to intermediates in bilirubin metabolism, including relationships involving the genes for the enzymes participating in those steps. Nevertheless, the pursuit of bilirubin in disease causation is opening new avenues for research and if it is established that serum bilirubin can predict risks, much will have been achieved. The answer may have to come from molecular genetic analyses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Diabetes and its Complications - Volume 30, Issue 4, MayâJune 2016, Pages 728-737
Journal: Journal of Diabetes and its Complications - Volume 30, Issue 4, MayâJune 2016, Pages 728-737
نویسندگان
Lars H. Breimer, Dimitri P. Mikhailidis,