کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5903755 1157105 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ginsenoside Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Ginsenoside Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats
چکیده انگلیسی

ObjectiveIn a previous study, it was found that a ginseng berry extract with a high content of the ginsenoside Re normalized blood glucose in ob/ob mice. The objective of this study was to evaluate the effect of the ginsenoside Re on insulin resistance of glucose transport in muscles of rats made insulin resistant with a high-fat diet.Material/methodRats were fed either rat chow or a high-fat diet for 5 weeks. The rats were then euthanized, and insulin stimulated glucose transport activity was measured in epitrochlearis and soleus muscle strips in vitro.ResultsTreatment of muscles with Re alone had no effect on glucose transport. The high-fat diet resulted in ~ 50% decreases in insulin responsiveness of GLUT4 translocation to the cell surface and glucose transport in epitrochlearis and soleus muscles. Treatment of muscles with Re in vitro for 90 min completely reversed the high-fat diet-induced insulin resistance of glucose transport and GLUT4 translocation. This effect of Re is specific for insulin stimulated glucose transport, as Re treatment did not reverse the high-fat diet-induced resistance of skeletal muscle glucose transport to stimulation by contractions or hypoxia.ConclusionsOur results show that the ginsenoside Re induces a remarkably rapid reversal of high-fat diet-induced insulin resistance of muscle glucose transport by reversing the impairment of insulin-stimulated GLUT4 translocation to the cell surface.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 61, Issue 11, November 2012, Pages 1615-1621
نویسندگان
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