کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5906343 | 1159970 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Relationship of polymorphisms within ZBED6 gene and growth traits in beef cattle
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کلمات کلیدی
QTNIGF2HWESNPsGLMPICSPSSElectrophoretic mobility shift assay - آزمون تحرک تحرک الکتروفورزeffective allele numbers - اعداد موثر آللAssociation analysis - تجزیه و تحلیل انجمنHardy–Weinberg equilibrium - تعادل هاردی-وینبرگBase pair(s) - جفت پایه (ها)Statistical Product and Service Solutions - راه حل های محصولات و خدمات آماریLSM - سازمان غیر دولتیEMSA یا electrophoretic mobility shift assay - سنجش تغییر تحرک الکتروفورتیکGrowth traits - صفات رشدLinkage disequilibrium - عدم تعادل پیوستگیinsulin-like growth factor 2 - فاکتور رشد مانند انسولین 2polymorphism information content - محتوای اطلاعات پلی مورفیسمGeneral linear models - مدل خطی عمومیQuantitative trait nucleotide - نوکلئوتید صفات کمیHeterozygosity - هتروزیگوزیتهChinese Holstein - هولشتاین چینیbody weight - وزن بدنSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیCattle - گاو
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
ZBED6 is a novel transcription factor that was identified and shown to act as a repressor of IGF2 transcription in skeletal muscle. The aim of this study was to examine the association of the ZBED6 polymorphism with growth traits in beef cattle breed. Three single nucleotide polymorphisms (SNPs) were identified in the bovine ZBED6 by sequencing pooled DNA samples (Pool-Seq) and forced polymerase chain reaction-restriction fragment length polymorphism (Forced PCR-RFLP) methods. Overall, we reported one mutation (SNP1) in the promoter region and two missense mutations (SNP2 and 3) in the coding region (single exon) within the bovine ZBED6 gene, and the haplotype variability and extent of linkage disequilibrium (LD) in 1522 individuals representing four main cattle breeds from China (Nanyang, NY; Qinchuan, QC; Jiaxian, JX; and Chinese Holstein, CH). We also investigated haplotype frequencies and linkage disequilibrium coefficients for three SNPs in all study populations. LD and haplotype structure of ZBED6 were different between breeds. The result of haplotype analysis of three SNPs showed that eight different haplotypes were identified in all breeds. The wild-type haplotype (Hap 1: GCA) and mutant-type haplotype (Hap 8: AGG) shared by all four populations accounted for 15.1, 29.8, 21.7, 57.5% and 9.5, 8.6, 16.7, 0% of all haplotypes were observed in NY, QC, JX and CH, respectively. The statistical analyses indicated that three SNPs were significantly associated with growth traits in NY cattle population (PÂ <Â 0.05 or PÂ <Â 0.01) at five different ages. The results of this study suggest that the ZBED6 gene possibly is a strong candidate gene that affects growth traits in beef cattle breeding program.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 526, Issue 2, 10 September 2013, Pages 107-111
Journal: Gene - Volume 526, Issue 2, 10 September 2013, Pages 107-111
نویسندگان
Yong-Zhen Huang, Hua He, Zhao-Yang Zhan, Yu-Jia Sun, Ming-Xun Li, Xian-Yong Lan, Chu-Zhao Lei, Chun-Lei Zhang, Hong Chen,